the effect of beta interferon on dendritic cells and cytokine synthesis by cd4+ t cells
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abstract
background: dendritic cells (dc) are a key regulator of the immune response, and interferon- beta (ifn-β) is considered an immunomodulatory molecule for dc. objective: the purpose of this study was to evaluate the ability of ifn-β treated dc to induce cytokine secretion by cd4+ t cells. methods: dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating factor and interleukin-4 with or without ifn-β. we analyzed the production of cd4+ t helper cytokines (il-17, ifn- γ and il-10) in the supernatant of the dendritic cell-t cell co- cultures by elisa. we also studied the effects of hla-g and costimulatory molecules on immature and mature dc. results: ifn-γ and il-17 decreased significantly in the presence of hla-gbearing dc compared to control cultures (p
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Journal title:
iranian journal of immunologyجلد ۶، شماره ۲، صفحات ۶۱-۶۶
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